Succinate oxidation
Succinate dehydrogenase oxidizes succinate to fumarate and reduces enzyme-bound FAD.
Citric acid cycle · irreversibleBUILD UP YOUR UNDERSTANDING
Learn about Fumarate
Fumarate is a small molecule that cells make, use, or change in connected metabolic reactions.
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QUICK FACTS
At a glance
Carbon backbone 4 CThis carbon count is shown where it is defined for the molecule.
FOLLOW THE BIOLOGY
10 linksConnected records
Used and produced inCitric acid cycleProduced inOxidative phosphorylationProduced inUrea cycleProduced inPurine nucleotide synthesisHandled bySuccinate dehydrogenaseHandled byFumaraseHandled byRespiratory complex IIHandled byArgininosuccinate lyase
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STRUCTURED REACTIONS
Open metabolism map Where it appears
Fumarate hydration
Fumarase adds water across the double bond of fumarate to form malate.
Citric acid cycle · reversibleSuccinate-linked electron entry
Complex II transfers succinate-derived electrons to ubiquinone without pumping protons.
Oxidative phosphorylation · irreversibleFumarate and arginine formation
Argininosuccinate lyase produces arginine and fumarate.
Urea cycle · irreversibleFumarate release
Adenylosuccinate lyase activity releases fumarate and forms AICAR.
Purine nucleotide synthesis · irreversibleAMP branch
The AMP branch uses aspartate and GTP to make AMP and fumarate.
Purine nucleotide synthesis · irreversible