Biomarker

Treponema pallidum antibodies

Treponemal antibodies to Treponema pallidum

Antibodies specific to the syphilis bacterium, detected by treponemal tests; they usually persist for life.

Overview

EXPLORE BY LEVEL

These show that a person has been infected with syphilis bacteria at some point.

Quick Facts

AT A GLANCE
MeasuresAntibodies against T. pallidum antigens
CategoryAntibody · syphilis serology
Interpretation limitTreponemal antibodies usually remain reactive for life regardless of treatment, so they do not show current disease activity; nontreponemal tests are also needed.

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Recommended Reading

Trusted references for learning more about Treponema pallidum antibodies.

Research Claims

Treponemal antibodies usually remain reactive for life regardless of treatment, so they do not show current disease activity; nontreponemal tests are also needed.

Because most treponemal tests stay reactive after treatment, serologic interpretation pairs them with nontreponemal titers and clinical history.