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Concept

Biased Agonism

Biased agonism

A ligand-dependent preference for some receptor signaling routes over others.

Overview

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A can send messages through more than one route. Some agonists favor one route more than another, so the cell's response can differ.

Quick Facts

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ConceptGPCR Agonists and antagonistschanges output of
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Biased Agonism · ConceptCHANGES OUTPUT OF →GPCR Agonists and antagonists · Concept

Recommended Reading

Trusted references for learning more about Biased Agonism.

pathwaySignaling by GPCR (R-HSA-372790)Reactome · Homo sapiens textbookGeneral Principles of Cell CommunicationMolecular Biology of the Cell · NCBI Bookshelf
Research Claims

Bias estimates require quantitative comparison across pathways with correction for system amplification and receptor expression. A ligand should not be described as universally biased without specifying the assay framework.