G6PD Deficiency
Glucose-6-phosphate dehydrogenase deficiency
Variants that reduce G6PD activity can leave red blood cells less able to manage oxidative stress.
Overview
EXPLORE BY LEVELG6PD is an A protein that speeds up a chemical reaction in a cell. in the pentose phosphate A set of connected chemical steps in a cell, where one reaction's products can feed another.. It helps red blood cells make An electron-carrying molecule that supplies reducing power for biosynthesis and cell protection., which supports protection from oxidative damage. Some G6PD variants can make red blood cells more vulnerable to breakdown during certain infections, medicines, or other triggers.
Quick Facts
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Research Claims
G6PD deficiency is X-linked and genetically heterogeneous. Residual enzyme activity, erythrocyte age distribution, sex and X-inactivation, and oxidative exposures influence phenotype. The pathway connection is biochemical context, not a prediction of an individual's clinical risk.