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Protein · enzymePROTEIN · ENZYME RECORD

Pyruvate kinase

Transfers the phosphate of PEP to ADP in a strongly exergonic reaction that requires Mg2+ and K+. Fructose 1,6-bisphosphate activates the PKM2 and liver isoforms (feed-forward activation).

GlycolysisHomo sapiens
REFERENCE IDENTIFIER2.7.1.40EC record
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Pyruvate kinase is a protein that speeds up a chemical reaction. Cells can adjust when and how strongly many enzymes work.

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Record type: enzyme. Transfers the phosphate of PEP to ADP in a strongly exergonic reaction that requires Mg2+ and K+. Fructose 1,6-bisphosphate activates the PKM2 and liver isoforms (feed-forward activation).
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At a glance

HUMAN GENESPKMExplore gene PKLR · liver and red blood cellsExplore gene
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Connected records

7 links
Catalyzes a step inGlycolysisUsesPhosphoenolpyruvateUsesADPProducesPyruvateProducesATPEncoded byPKMEncoded byPKLR
STRUCTURED REACTIONS

Reactions it catalyzes

Open metabolism map
10

Second ATP-generating step

PEP gives its phosphate to ADP, forming ATP and pyruvate. This second ATP-making step is where glycolysis turns a net profit.

Glycolysis · irreversible