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HomeMetabolismPhosphoenolpyruvate
MoleculeMETABOLITE RECORD

Phosphoenolpyruvate

An enol phosphate with very high phosphoryl-transfer potential.

3-carbon moleculeGlycolysisHomo sapiens
REFERENCE IDENTIFIERCHEBI:18021ChEBI record
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Learn about Phosphoenolpyruvate

Phosphoenolpyruvate is a small molecule that cells make, use, or change in connected metabolic reactions.

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Record type: molecule. An enol phosphate with very high phosphoryl-transfer potential.
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At a glance

Carbon backbone 3 CThis carbon count is shown where it is defined for the molecule.

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Connected records

5 links
Used and produced inGlycolysisUsed and produced inGluconeogenesisHandled byEnolaseHandled byPyruvate kinaseHandled byPhosphoenolpyruvate carboxykinase (cytosolic)
STRUCTURED REACTIONS

Where it appears

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9

Dehydration to phosphoenolpyruvate

Removing a water molecule forms phosphoenolpyruvate, whose phosphate has very high transfer potential.

Glycolysis · reversible
10

Second ATP-generating step

PEP gives its phosphate to ADP, forming ATP and pyruvate. This second ATP-making step is where glycolysis turns a net profit.

Glycolysis · irreversible
2

Conversion of oxaloacetate to phosphoenolpyruvate

PEP carboxykinase uses GTP to decarboxylate and phosphorylate oxaloacetate.

Gluconeogenesis · irreversible
3

Reverse the glycolytic payoff sequence

The reversible lower-glycolysis reactions proceed from PEP toward glyceraldehyde 3-phosphate.

Gluconeogenesis · reversible