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Molecular complex

Hemoglobin S

Hemoglobin S

A hemoglobin tetramer containing sickle beta-globin subunits; deoxygenated molecules can polymerize under susceptible intracellular conditions.

Overview

EXPLORE BY LEVEL

S carries oxygen like other , but when oxygen is low its altered beta chains can make HbS molecules assemble into long fibers.

Quick Facts

AT A GLANCE
TopicHeredity & Cell Division

Follow the Connections

See how Hemoglobin S links to other biological records.

Open network
VariantHbS β6 Glu→Val Variantcontributes subunit toDiseaseSickle Cell diseasecan contribute to
All 2 Structured Connections
HbS β6 Glu→Val Variant · VariantCONTRIBUTES SUBUNIT TO →Hemoglobin S · Molecular complex
Hemoglobin S · Molecular complexCAN CONTRIBUTE TO →Sickle Cell disease · Disease

Recommended Reading

Trusted references for learning more about Hemoglobin S.

databaseHemoglobin subunit beta (P68871)UniProtKB articleDetermination of deoxyhemoglobin S polymer in sickle erythrocytes upon deoxygenationNoble et al. · PMID 6933568
Research Claims

Polymerization kinetics depend on deoxy-HbS concentration, oxygen saturation, hemoglobin composition, pH, and other intracellular conditions. Polymerization risk is not a deterministic proxy for clinical events.