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HomeMetabolism2-Oxoglutarate
MoleculeMETABOLITE RECORD

2-Oxoglutarate

A five-carbon citric acid cycle intermediate also called alpha-ketoglutarate.

5-carbon moleculeCitric acid cycleHomo sapiens
REFERENCE IDENTIFIERCHEBI:16810ChEBI record
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Learn about 2-Oxoglutarate

2-Oxoglutarate is a small molecule that cells make, use, or change in connected metabolic reactions.

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Record type: molecule. A five-carbon citric acid cycle intermediate also called alpha-ketoglutarate.
QUICK FACTS

At a glance

Carbon backbone 5 CThis carbon count is shown where it is defined for the molecule.

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Connected records

5 links
Used and produced inCitric acid cycleUsed inBranched-chain amino acid catabolismHandled byNAD-dependent isocitrate dehydrogenaseHandled by2-Oxoglutarate dehydrogenase complexHandled byBranched-chain amino-acid aminotransferase
STRUCTURED REACTIONS

Where it appears

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3

First oxidative decarboxylation

NAD-dependent isocitrate dehydrogenase produces 2-oxoglutarate, CO2, and NADH.

Citric acid cycle · irreversible
4

Second oxidative decarboxylation

The 2-oxoglutarate dehydrogenase complex forms succinyl-CoA, CO2, and NADH.

Citric acid cycle · irreversible