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HomeMetabolismFructose 1,6-bisphosphate
MoleculeMETABOLITE RECORD

Fructose 1,6-bisphosphate

A six-carbon sugar with phosphates on carbons 1 and 6, ready to be split in half.

6-carbon moleculeGlycolysisHomo sapiens
REFERENCE IDENTIFIERCHEBI:16905ChEBI record
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Learn about Fructose 1,6-bisphosphate

Fructose 1,6-bisphosphate is a small molecule that cells make, use, or change in connected metabolic reactions.

Start here for the main idea. Choose Learn for reactions and connections.

Record type: molecule. A six-carbon sugar with phosphates on carbons 1 and 6, ready to be split in half.
QUICK FACTS

At a glance

Carbon backbone 6 CThis carbon count is shown where it is defined for the molecule.

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Connected records

5 links
Used and produced inGlycolysisUsed inGluconeogenesisHandled byPhosphofructokinase-1Handled byFructose-bisphosphate aldolaseHandled byFructose-1,6-bisphosphatase
STRUCTURED REACTIONS

Where it appears

Open metabolism map
3

Phosphorylation of fructose 6-phosphate

A second ATP adds a phosphate to carbon 1. This commits the sugar to glycolysis and is the pathway's main control point.

Glycolysis · irreversible
4

Cleavage into two triose phosphates

The six-carbon sugar splits into two three-carbon sugars: DHAP and glyceraldehyde 3-phosphate.

Glycolysis · reversible
4

Fructose 1,6-bisphosphate dephosphorylation

Fructose-1,6-bisphosphatase bypasses the irreversible PFK-1 step by hydrolysis.

Gluconeogenesis · irreversible