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HomeMetabolismPhosphofructokinase-1
Protein · enzymePROTEIN · ENZYME RECORD

Phosphofructokinase-1

Catalyzes the committed step of glycolysis. It is inhibited by ATP and citrate and activated by AMP and fructose 2,6-bisphosphate.

GlycolysisHomo sapiens
REFERENCE IDENTIFIER2.7.1.11EC record
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Learn about Phosphofructokinase-1

Phosphofructokinase-1 is a protein that speeds up a chemical reaction. Cells can adjust when and how strongly many enzymes work.

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Record type: enzyme. Catalyzes the committed step of glycolysis. It is inhibited by ATP and citrate and activated by AMP and fructose 2,6-bisphosphate.
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At a glance

HUMAN GENESPFKL · liverExplore gene PFKM · muscleExplore gene PFKP · plateletExplore gene
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Connected records

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Catalyzes a step inGlycolysisUsesFructose 6-phosphateUsesATPProducesFructose 1,6-bisphosphateProducesADPEncoded byPFKLEncoded byPFKMEncoded byPFKP
STRUCTURED REACTIONS

Reactions it catalyzes

Open metabolism map
3

Phosphorylation of fructose 6-phosphate

A second ATP adds a phosphate to carbon 1. This commits the sugar to glycolysis and is the pathway's main control point.

Glycolysis · irreversible