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Molecule

Reduced Glutathione (GSH)

γ-glutamyl-cysteinyl-glycine, reduced form

GSH is a small antioxidant molecule used by enzymes such as GPX1 to reduce peroxides.

Overview

EXPLORE BY LEVEL

Reduced glutathione (GSH) helps cells handle some reactive molecules. Enzymes use it in reactions that can turn peroxides into water.

Quick Facts

AT A GLANCE
Redox pairGSSG / GSH

Follow the Connections

See how Reduced Glutathione (GSH) links to other biological records.

Open network
ProteinGlutathione ReductaseregeneratesMoleculeOxidized Glutathione (GSSG)reduced toProteinGlutathione Peroxidase 1uses
All 3 Structured Connections
Glutathione Reductase · ProteinREGENERATES →Reduced Glutathione (GSH) · Molecule
Oxidized Glutathione (GSSG) · MoleculeREDUCED TO →Reduced Glutathione (GSH) · Molecule
Glutathione Peroxidase 1 · ProteinUSES →Reduced Glutathione (GSH) · Molecule

Recommended Reading

Trusted references for learning more about Reduced Glutathione (GSH).

reviewImpact of G6PD status on red cell storage and transfusion outcomesTransfusion Medicine Reviews · PMC6683872 databaseGSR glutathione-disulfide reductase (Gene ID 2936)NCBI Gene databaseGPX1 glutathione peroxidase 1 (Gene ID 2876)NCBI Gene
Research Claims

Glutathione peroxidases use GSH to reduce peroxides, producing GSSG.