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Molecule

Mannose-6-Phosphate

Mannose-6-Phosphate

A carbohydrate phosphate tag recognized by mannose-6-phosphate receptors on many soluble lysosomal enzyme cargos.

Overview

EXPLORE BY LEVEL

Mannose-6-phosphate is a small chemical tag attached to many lysosomal enzymes. A matching can recognize it and help route the toward a lysosome.

Quick Facts

AT A GLANCE
Explore nextMolecular medicine

Follow the Connections

See how Mannose-6-Phosphate links to other biological records.

Open network
ProteinCI-MPR (IGF2R)recognized by
All 1 Structured Connections
Mannose-6-Phosphate · MoleculeRECOGNIZED BY →CI-MPR (IGF2R) · Protein

Recommended Reading

Trusted references for learning more about Mannose-6-Phosphate.

textbookProtein Sorting and TransportThe Cell · NCBI Bookshelf articleExploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapyScience Advances · PMID 33310843
Research Claims

M6P is one lysosomal sorting signal rather than a universal lysosomal address. Therapeutic uptake depends on glycan structure, receptor expression, cell type, and the particular enzyme product.