Pathway
JAK–STAT Signaling
JAK–STAT signaling
A direct route from selected cytokine receptors to transcriptional responses.
Overview
EXPLORE BY LEVELSome immune and hormone signals activate proteins called STATs, which travel to the nucleus and help switch genes on or off.
Quick Facts
AT A GLANCEExplore nextCell signaling
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Recommended Reading
Trusted references for learning more about JAK–STAT Signaling.
Research Claims
JAK–STAT signaling is shaped by receptor composition, STAT family members, SOCS feedback, phosphatases, and chromatin context.