RAS-RAF-MEK-ERK Signaling (MAPK)
Human RAF/MAP kinase cascade
A growth-signal network whose core RAS-RAF-MEK-ERK relay regulates cell responses, with output shaped by feedback, location, and cell context.
Overview
EXPLORE BY LEVELA signal at a cell surface can switch RAS into an active state. RAS can engage RAF, which activates MEK, then ERK. ERK changes the activity of proteins in the cytoplasm and nucleus. This is a common route, not a fixed chain used identically by every cell.
Quick Facts
AT A GLANCEFollow the Connections
See how RAS-RAF-MEK-ERK Signaling (MAPK) links to other biological records.
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Recommended Reading
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Research Claims
Reactome's human RAF/MAP kinase cascade (R-HSA-5673001) represents a reviewed core module, not the full MAPK family network. RAS isoforms and effectors, RAF dimers, scaffold proteins, feedback, subcellular location, and cell state alter signal dynamics and output. Pathway membership alone does not establish a causal phenotype or predict response to perturbation.