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Crossing The blood–brain barrier

Crossing the blood–brain barrier

A delivery challenge because many therapeutic proteins and other large molecules do not readily enter the brain from blood.

Overview

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The brain has a protective barrier that keeps many substances in the blood from entering. That protection can also make it hard for a medicine to reach brain cells.

Quick Facts

AT A GLANCE
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TherapyEnzyme Replacement therapylimits access of
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Crossing The blood–brain barrier · ProcessLIMITS ACCESS OF →Enzyme Replacement therapy · Therapy

Recommended Reading

Trusted references for learning more about Crossing The blood–brain barrier.

textbookProtein Sorting and TransportThe Cell · NCBI Bookshelf databaseGaucher diseaseMedlinePlus Genetics
Research Claims

CNS exposure depends on molecular properties, transporter engagement, disease state, and barrier integrity. A delivery strategy must demonstrate target-tissue exposure and pharmacologic activity, not just blood concentration.