Process
Endosomal Escape
Endosomal escape
The release of internalized therapeutic molecules from endosomes into the cytoplasm or other site where their target resides.
Overview
EXPLORE BY LEVELCells often trap incoming molecules inside small membrane bubbles called endosomes. An RNA drug may need to escape that bubble before it can reach its target.
Quick Facts
AT A GLANCEExplore nextRNA therapeutics
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Recommended Reading
Trusted references for learning more about Endosomal Escape.
Research Claims
Endosomal escape is a major but incompletely understood bottleneck. Uptake, trafficking, escape efficiency, toxicity, and tissue specificity must be evaluated separately.