Process

Substrate-level Phosphorylation

Substrate-level phosphorylation

Direct formation of ATP or GTP when an enzyme transfers a phosphate group from a reaction intermediate.

Overview

EXPLORE BY LEVEL

A cell can make ATP by moving a phosphate directly from one molecule onto ADP. Glycolysis uses this method.

Quick Facts

AT A GLANCE

Explore nextMetabolism

Follow the Connections

See how Substrate-level Phosphorylation links to other biological records.

PathwayGlycolysisoccurs in

All 1 Structured Connections

Substrate-level Phosphorylation · ProcessOCCURS IN →Glycolysis · Pathway

Recommended Reading

Trusted references for learning more about Substrate-level Phosphorylation.

textbookMolecular Biology of the Cell: glycolysis (NBK26882)Alberts et al. · NCBI Bookshelf textbookCatalysis and the Use of Energy by CellsMolecular Biology of the Cell · NCBI Bookshelf

Research Claims

The term describes direct phosphoryl-group transfer to a nucleoside diphosphate. It occurs in selected cytosolic and mitochondrial reactions and does not require the respiratory proton gradient itself.

[1] Alberts et al. · NCBI Bookshelf · [2] Molecular Biology of the Cell · NCBI Bookshelf