BASEBiological Archive
for Science & Education
Search
HomeExploreDNA-encoded Libraries
Technique

DNA-encoded Libraries

DNA-encoded libraries

Collections of small molecules tagged with DNA barcodes that record each compound's identity during pooled binding selections.

Overview

EXPLORE BY LEVEL

Each small molecule in a DNA-encoded library carries a short DNA tag like an ID card. After molecules are tested against a protein, researchers read the tags to learn which compounds were retained.

Quick Facts

AT A GLANCE
Explore nextDrug discovery

Follow the Connections

See how DNA-encoded Libraries links to other biological records.

Open network
TechniqueHigh-throughput Screeningcan useConceptProtein Binding pocketscan identify binders to
All 2 Structured Connections
High-throughput Screening · TechniqueCAN USE →DNA-encoded Libraries · Technique
DNA-encoded Libraries · TechniqueCAN IDENTIFY BINDERS TO →Protein Binding pockets · Concept

Recommended Reading

Trusted references for learning more about DNA-encoded Libraries.

reviewAn overview of DNA-encoded libraries: A versatile tool for drug discoveryPubMed
Research Claims

DEL selection can efficiently identify binders from very large collections, but results depend on target presentation, selection conditions, DNA-compatible chemistry, amplification bias, and post-selection validation. Binding enrichment does not prove functional activity.