Technique
Phage Display
Phage display
A selection method that links a displayed peptide or antibody fragment to the genetic sequence that encodes it.
Overview
EXPLORE BY LEVELA harmless bacterial An infectious agent that is not a cell and must use a host cell to make new virus particles. can display a protein fragment on its surface while carrying the gene for that fragment inside. Researchers keep the phages that bind a target and read their genes to identify the binder.
Quick Facts
AT A GLANCEExplore nextDrug discovery
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Research Claims
Selection outcomes depend on library diversity, target immobilization, epitope accessibility, avidity, washing stringency, and amplification. Binding clones require functional, specificity, and developability testing.