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Biomarker

Anti-HBc (total)

Total antibody to hepatitis B core antigen

Total antibody to hepatitis B core antigen, indicating past or current HBV infection; vaccination does not produce it.

Overview

EXPLORE BY LEVEL

is an people make only after being infected with hepatitis B, not after the .

Quick Facts

AT A GLANCE
MeasuresAntibodies (IgM and IgG) against the HBV core antigen
CategoryAntibody · HBV serology
HBV panelsIn CDC's initial triple panel and the older five-marker panel
Interpretation limitTotal anti-HBc shows past or current infection but not which; IgM anti-HBc is the marker of acute infection.

Follow the Connections

See how Anti-HBc (total) links to other biological records.

Open network
OrganismHepatitis B virusantibody toDiseaseHepatitis Bmarker for
All 2 Structured Connections
Anti-HBc (total) · BiomarkerANTIBODY TO →Hepatitis B virus · Organism
Anti-HBc (total) · BiomarkerMARKER FOR →Hepatitis B · Disease

Recommended Reading

Trusted references for learning more about Anti-HBc (total).

guideClinical Testing and Diagnosis for Hepatitis BCenters for Disease Control and Prevention guideHepatitis TestingMedlinePlus Medical Tests textbookHepatitis B (Epidemiology and Prevention of Vaccine-Preventable Diseases)Centers for Disease Control and Prevention · Pink Book guideScreening and Testing for Hepatitis B Virus Infection: CDC Recommendations — United States, 2023MMWR Recommendations and Reports
Research Claims

Total anti-HBc shows past or current infection but not which; IgM anti-HBc is the marker of acute infection.

Total anti-HBc is in CDC's triple panel partly to find resolved infection, which carries a risk of reactivation during immunosuppression. IgM anti-HBc is the best serologic marker of acute infection.