Disease

Hepatitis B

Hepatitis B virus infection

Liver infection caused by hepatitis B virus; it can be acute or chronic and is preventable by vaccination.

WORLD HEALTH ORGANIZATION IDENTIFIERHepatitis BView source record ↗

Overview

EXPLORE BY LEVEL

Hepatitis B is a liver infection caused by a that spreads through blood and other body fluids. A prevents it. Blood tests look for pieces of the and for the body makes against it.

Quick Facts

AT A GLANCE
CauseHepatitis B virus
CDC initial screening panel (2023)Triple panel: HBsAg, anti-HBs, total anti-HBc
Older five-marker serology panelHBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc — not the same as CDC's current initial triple panel

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Research Claims

CDC's 2023 guidance recommends screening all adults at least once with the triple panel, which separates current infection, resolved infection with reactivation risk, susceptibility, and vaccine immunity. The older five-marker panel is not the same test set: it adds HBeAg and anti-HBe, which help stage a known infection rather than screen for one. HBV DNA and clinical evaluation are needed to manage chronic infection.

CDC's 2023 recommendation for initial adult screening is the triple panel (HBsAg, anti-HBs, total anti-HBc). The older five-marker panel adds HBeAg and anti-HBe, which describe replication status in a known infection rather than serving as initial screening markers.