Cell component

Endosome

Endosome

A membrane-bound sorting compartment that receives endocytosed cargo and routes it for recycling, further transport, or degradation.

Overview

EXPLORE BY LEVEL

An endosome is a small membrane bubble inside a cell. It sorts material brought in from outside or moved from other cell compartments.

Quick Facts

AT A GLANCE

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Follow the Connections

See how Endosome links to other biological records.

ProcessMannose-6-phosphate Lysosomal targetingtraffics selected cargo toward ProcessEndocytosisdelivers internalized cargo to Cell componentLysosomecan route cargo to

All 3 Structured Connections

Mannose-6-phosphate Lysosomal targeting · ProcessTRAFFICS SELECTED CARGO TOWARD →Endosome · Cell component

Endocytosis · ProcessDELIVERS INTERNALIZED CARGO TO →Endosome · Cell component

Endosome · Cell componentCAN ROUTE CARGO TO →Lysosome · Cell component

Recommended Reading

Trusted references for learning more about Endosome.

textbookProtein Sorting and TransportThe Cell · NCBI Bookshelf articleExploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapyScience Advances · PMID 33310843 reviewCurrent Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAsPubMed Central textbookMembrane Transport and Electrical PropertiesMolecular Biology of the Cell · NCBI Bookshelf

Research Claims

Endosomal identity and trafficking reflect Rab GTPases, lipid composition, acidification, cargo adaptors, and maturation. Endocytic uptake alone does not establish delivery to the cytosol or lysosome.

[1] The Cell · NCBI Bookshelf · [2] Science Advances · PMID 33310843 · [3] PubMed Central