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Mannose-6-phosphate Lysosomal targeting

Mannose-6-phosphate lysosomal targeting

A sorting signal used by many soluble lysosomal enzymes to reach lysosomes through receptor-mediated trafficking.

Overview

EXPLORE BY LEVEL

Many lysosomal enzymes carry a small chemical tag called mannose-6-phosphate. A recognizes the tag and helps deliver the to a lysosome.

Quick Facts

AT A GLANCE
Explore nextMolecular medicine

Follow the Connections

See how Mannose-6-phosphate Lysosomal targeting links to other biological records.

Open network
TherapyEnzyme Replacement therapycan useCell componentLysosometraffics cargo toProteinCI-MPR (IGF2R)recognized byCell componentEndosometraffics selected cargo toward
All 6 Structured Connections
Enzyme Replacement therapy · TherapyCAN USE →Mannose-6-phosphate Lysosomal targeting · Process
Mannose-6-phosphate Lysosomal targeting · ProcessTRAFFICS CARGO TO →Lysosome · Cell component
Mannose-6-phosphate Lysosomal targeting · ProcessRECOGNIZED BY →CI-MPR (IGF2R) · Protein
Mannose-6-phosphate Lysosomal targeting · ProcessTRAFFICS SELECTED CARGO TOWARD →Endosome · Cell component
Enzyme Replacement therapy · TherapyCAN USE →Mannose-6-phosphate Lysosomal targeting · Process
CI-MPR (IGF2R) · ProteinPARTICIPATES IN →Mannose-6-phosphate Lysosomal targeting · Process

Recommended Reading

Trusted references for learning more about Mannose-6-phosphate Lysosomal targeting.

textbookProtein Sorting and TransportThe Cell · NCBI Bookshelf databaseGaucher diseaseMedlinePlus Genetics articleExploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapyScience Advances · PMID 33310843 databaseIGF2R (3482)NCBI Gene
Research Claims

M6P-dependent trafficking is one of several lysosomal sorting routes. Receptor expression, cargo glycosylation, cell type, and endosomal processing affect uptake and lysosomal delivery.