Concept
GTPase-activating Proteins
GTPase-activating proteins
Proteins that accelerate GTP hydrolysis by a GTPase, helping return the switch toward its GDP-bound state.
Overview
EXPLORE BY LEVELA GAP helps a GTPase switch break down its bound GTP. This usually turns the switch's signal down.
Quick Facts
AT A GLANCEExplore nextCell signaling
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Research Claims
GAP specificity, catalytic contribution, and regulation vary across GTPase families. Loss of GAP function can prolong signaling, but cellular outcomes depend on network context.