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The Small GTPase switch

The small GTPase switch

A molecular switch in which a small GTPase's bound GDP or GTP helps control its interactions with signaling partners.

Overview

EXPLORE BY LEVEL

Some proteins act like switches. When they hold GDP they are usually less active; when they hold GTP they can bind partners and pass a signal.

Quick Facts

AT A GLANCE
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Follow the Connections

See how The Small GTPase switch links to other biological records.

Open network
ConceptGuanine Nucleotide exchange factorsregulated byConceptGTPase-activating Proteinsregulated byConceptGuanine Nucleotide dissociation inhibitorsregulates selected families ofVariantKRAS G12Cis a variant of
All 4 Structured Connections
The Small GTPase switch · ProcessREGULATED BY →Guanine Nucleotide exchange factors · Concept
The Small GTPase switch · ProcessREGULATED BY →GTPase-activating Proteins · Concept
Guanine Nucleotide dissociation inhibitors · ConceptREGULATES SELECTED FAMILIES OF →The Small GTPase switch · Process
KRAS G12C · VariantIS A VARIANT OF →The Small GTPase switch · Process

Recommended Reading

Trusted references for learning more about The Small GTPase switch.

reviewTargeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRASPubMed · PMID 37221195 textbookGeneral Principles of Cell CommunicationMolecular Biology of the Cell · NCBI Bookshelf
Research Claims

Nucleotide-state cycling is regulated by GEFs, GAPs, GDIs for selected GTPase families, membrane localization, and feedback. The exact regulators and effectors vary among Ras, Rho, Rab, Arf, and Ran families.