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Concept

Guanine Nucleotide dissociation inhibitors

Guanine nucleotide dissociation inhibitors

Regulators that bind GDP-bound members of selected small GTPase families and can influence their activity and localization.

Overview

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Some GTPases have helper proteins called GDIs. A GDI can bind the GDP-bound switch and affect where it sits in the cell and how it is reused.

Quick Facts

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ProcessThe Small GTPase switchregulates selected families of
All 1 Structured Connections
Guanine Nucleotide dissociation inhibitors · ConceptREGULATES SELECTED FAMILIES OF →The Small GTPase switch · Process

Recommended Reading

Trusted references for learning more about Guanine Nucleotide dissociation inhibitors.

reviewTargeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRASPubMed · PMID 37221195
Research Claims

GDI control integrates nucleotide state with lipid anchoring and membrane trafficking. Family-specific interactions determine whether a GDI extracts, sequesters, or redistributes a GTPase.