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Concept

Guanine Nucleotide exchange factors

Guanine nucleotide exchange factors

Proteins that help a GTPase release GDP so GTP can bind and activate the switch.

Overview

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A GEF helps a molecular switch let go of GDP. Because GTP is available in the cell, it can then bind and turn the switch on.

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AT A GLANCE
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ProcessThe Small GTPase switchregulated by
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The Small GTPase switch · ProcessREGULATED BY →Guanine Nucleotide exchange factors · Concept

Recommended Reading

Trusted references for learning more about Guanine Nucleotide exchange factors.

reviewTargeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRASPubMed · PMID 37221195
Research Claims

GEF activity is controlled by localization, conformational regulation, scaffolds, and upstream signals. Substrate specificity differs across small GTPase families.