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Molecular Glues

Molecular glues

Small molecules that stabilize or create an interaction between proteins, changing the function or fate of one or both partners.

Overview

EXPLORE BY LEVEL

A molecular glue is a small molecule that helps two proteins stick together. That new partnership can change what the proteins do.

Quick Facts

AT A GLANCE
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Follow the Connections

See how Molecular Glues links to other biological records.

Open network
VariantKRAS G12Ccan stabilize
All 1 Structured Connections
Molecular Glues · ConceptCAN STABILIZE →KRAS G12C · Variant

Recommended Reading

Trusted references for learning more about Molecular Glues.

reviewTargeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRASPubMed · PMID 37221195 articleMEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cellsPubMed · PMID 37336286
Research Claims

Molecular-glue activity is highly context-dependent and often discovered through phenotype-first or interaction-focused screens. A proposed ternary complex requires structural and functional validation.