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Variant

KRAS G12C

KRAS G12C

A KRAS variant that replaces glycine at position 12 with cysteine and creates a chemically addressable feature in the protein.

Overview

EXPLORE BY LEVEL

KRAS is a molecular switch used in growth signaling. In the G12C version, one changes to cysteine, creating a feature some medicines can recognize.

Quick Facts

AT A GLANCE
Explore nextMolecular medicine

Follow the Connections

See how KRAS G12C links to other biological records.

Open network
ConceptMolecular Gluescan stabilizeProcessThe Small GTPase switchis a variant ofProcessCovalent KRAS inhibitiontargetsProteinKRASvariant of
All 4 Structured Connections
Molecular Glues · ConceptCAN STABILIZE →KRAS G12C · Variant
KRAS G12C · VariantIS A VARIANT OF →The Small GTPase switch · Process
Covalent KRAS inhibition · ProcessTARGETS →KRAS G12C · Variant
KRAS G12C · VariantVARIANT OF →KRAS · Protein

Recommended Reading

Trusted references for learning more about KRAS G12C.

reviewTargeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRASPubMed · PMID 37221195 articleMEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cellsPubMed · PMID 37336286
Research Claims

KRAS G12C biology depends on nucleotide cycling, upstream exchange, effector engagement, tumor lineage, and feedback. Mutant-specific binding does not remove pathway adaptation or acquired resistance.