Beta Thalassemia
HBB-related reduced beta-globin production
A group of inherited blood disorders in which HBB variants reduce or prevent beta-globin production, limiting functional hemoglobin and healthy red blood cells.
Overview
EXPLORE BY LEVELBeta thalassemia happens when inherited HBB changes make too little A protein subunit that joins alpha-globin and heme to make hemoglobin., one of The protein in red blood cells that binds and carries oxygen.'s parts. With less working The protein in red blood cells that binds and carries oxygen., red blood cells develop poorly and the body may not carry oxygen as well.
Quick Facts
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Recommended Reading
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Research Claims
HBB variants that reduce or prevent beta-globin production cause beta thalassemia; frequency varies geographically.