HBB
hemoglobin subunit beta
HBB provides instructions for beta-globin, one of the protein subunits in adult hemoglobin. Particular HBB variants produce hemoglobin S and can cause sickle cell disease when inherited in disease-associated combinations.
Overview
EXPLORE BY LEVELHBB is a gene that helps cells make A protein subunit that joins alpha-globin and heme to make hemoglobin.. A protein subunit that joins alpha-globin and heme to make hemoglobin. joins other parts to build The protein in red blood cells that binds and carries oxygen., the protein red blood cells use to carry oxygen. Some changes in HBB make an unusual A protein subunit that joins alpha-globin and heme to make hemoglobin. called The protein in red blood cells that binds and carries oxygen. S; when a person inherits disease-causing HBB copies, red blood cells can become stiff and sickle-shaped.
Quick Facts
AT A GLANCEFollow the Connections
See how HBB links to other biological records.
All 5 Structured Connections
Recommended Reading
Trusted references for learning more about HBB.
Research Claims
HBB encodes beta-globin, a component of hemoglobin; the HbS variant replaces glutamate with valine at beta-globin position 6.
HBB variants cause sickle cell disease and beta thalassemia; disease severity and type depend on the inherited allele combination.