Isomerization to fructose 6-phosphate
The ring is rearranged, turning glucose 6-phosphate into fructose 6-phosphate.
Glycolysis · reversibleBUILD UP YOUR UNDERSTANDING
Learn about Fructose 6-phosphate
Fructose 6-phosphate is a small molecule that cells make, use, or change in connected metabolic reactions.
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QUICK FACTS
At a glance
Carbon backbone 6 CThis carbon count is shown where it is defined for the molecule.
FOLLOW THE BIOLOGY
8 linksConnected records
STRUCTURED REACTIONS
Open metabolism map Where it appears
Phosphorylation of fructose 6-phosphate
A second ATP adds a phosphate to carbon 1. This commits the sugar to glycolysis and is the pathway's main control point.
Glycolysis · irreversibleFructose 1,6-bisphosphate dephosphorylation
Fructose-1,6-bisphosphatase bypasses the irreversible PFK-1 step by hydrolysis.
Gluconeogenesis · irreversibleIsomerization and glucose 6-phosphate formation
The remaining shared upper-glycolysis reactions form glucose 6-phosphate.
Gluconeogenesis · irreversibleThree-carbon transfer
Transaldolase transfers a three-carbon unit to form erythrose 4-phosphate and fructose 6-phosphate.
Pentose phosphate pathway · reversibleSecond two-carbon transfer
A second transketolase reaction yields another fructose 6-phosphate and glyceraldehyde 3-phosphate.
Pentose phosphate pathway · reversible