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Gene

TP53

tumor protein p53

A protein-coding gene whose product helps cells respond to stress by regulating cell-cycle arrest, DNA repair, senescence, and apoptosis.

NCBI GENE IDENTIFIER7157View source record ↗

Overview

EXPLORE BY LEVEL

TP53 is a gene that gives cells instructions for making p53. When a cell is under stress, p53 can help pause cell division so damage can be repaired, or help the cell die if the damage is too severe.

Quick Facts

AT A GLANCE
OrganismHomo sapiens
Chromosome17p13.1
Gene ID7157
ProductCellular tumor antigen p53

Follow the Connections

See how TP53 links to other biological records.

Open network
Proteinp53encodesOrganismHomo sapiensfound in
All 2 Structured Connections
TP53 · GeneENCODES →p53 · Protein
TP53 · GeneFOUND IN →Homo sapiens · Organism

Recommended Reading

Trusted references for learning more about TP53.

databaseTP53 tumor protein p53 (Gene ID 7157)NCBI Gene databaseCellular tumor antigen p53 (P04637)UniProtKB reviewUnravelling mechanisms of p53-mediated tumour suppressionNature Reviews Cancer · PMID 24739573
Research Claims

TP53 is located at 17p13.1 and encodes p53.

The p53 response can include cell-cycle arrest, DNA repair, senescence, and apoptosis.