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Protein

p53

Cellular tumor antigen p53

A 393-amino-acid transcription factor that helps determine how a stressed cell responds to damage.

UNIPROT IDENTIFIERP04637View source record ↗

Overview

EXPLORE BY LEVEL

p53 is a protein made from the TP53 gene. It helps a cell decide whether to pause, repair damage, or stop growing when something goes wrong.

Quick Facts

AT A GLANCE
Encoded byTP53
Length393 amino acids
OrganismHomo sapiens
Primary roleTranscription factor

Follow the Connections

See how p53 links to other biological records.

Open network
GeneTP53encodesPathwayp53 Signalingparticipates inProcessApoptosisassociated withGeneCDKN1Aregulates
All 5 Structured Connections
TP53 · GeneENCODES →p53 · Protein
p53 · ProteinPARTICIPATES IN →p53 Signaling · Pathway
p53 · ProteinASSOCIATED WITH →Apoptosis · Process
p53 · ProteinREGULATES →CDKN1A · Gene
MDM2 · GeneREGULATES →p53 · Protein

Recommended Reading

Trusted references for learning more about p53.

databaseCellular tumor antigen p53 (P04637)UniProtKB databaseTP53 tumor protein p53 (Gene ID 7157)NCBI Gene reviewUnravelling mechanisms of p53-mediated tumour suppressionNature Reviews Cancer · PMID 24739573 pathwayStabilization of p53 (R-HSA-69541)Reactome
Show 2 more sources
CDKN1A cyclin dependent kinase inhibitor 1A (Gene ID 1026)NCBI Gene · databaseMDM2 proto-oncogene (Gene ID 4193)NCBI Gene · database
Research Claims

The reviewed human p53 protein contains 393 amino acids.

p53 regulates genes involved in cell-cycle arrest and apoptosis.