BASEBiological Archive
for Science & Education
Search
HomeExploreAdult Hemoglobin A
Molecular complex

Adult Hemoglobin A

hemoglobin alpha2-beta2 tetramer

Hemoglobin A is the main adult hemoglobin, assembled from two alpha-globin and two beta-globin subunits, each bound to heme.

REACTOME IDENTIFIERR-ICO-012815View source record ↗

Overview

EXPLORE BY LEVEL

A is a four-part protein inside red blood cells. It picks up oxygen in the lungs and lets go of oxygen in other tissues. Each part holds a small iron-containing group.

Quick Facts

AT A GLANCE
Composition2 alpha-globin + 2 beta-globin
Heme groups4
Main roleReversible oxygen transport in blood

Follow the Connections

See how Adult Hemoglobin A links to other biological records.

Open network
ProteinBeta-globinsubunit ofPathwayOxygen Exchange in red blood cellsparticipates inPathwayHeme Biosynthesissupplies cofactor forDiseaseSickle Cell diseaseaffects
All 4 Structured Connections
Beta-globin · ProteinSUBUNIT OF →Adult Hemoglobin A · Molecular complex
Adult Hemoglobin A · Molecular complexPARTICIPATES IN →Oxygen Exchange in red blood cells · Pathway
Heme Biosynthesis · PathwaySUPPLIES COFACTOR FOR →Adult Hemoglobin A · Molecular complex
Sickle Cell disease · DiseaseAFFECTS →Adult Hemoglobin A · Molecular complex

Recommended Reading

Trusted references for learning more about Adult Hemoglobin A.

databaseHemoglobin (R-ICO-012815)Reactome databaseHBB geneMedlinePlus Genetics pathwayO2/CO2 exchange in erythrocytes (R-HSA-1480926)Reactome · Homo sapiens pathwayHeme biosynthesis (R-HSA-189451)Reactome · Homo sapiens
Show 1 more sources
Sickle cell diseaseMedlinePlus Genetics · database
Research Claims

Adult hemoglobin contains two alpha-globin and two beta-globin subunits, each associated with heme.