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Molecular complex

mTORC1

Mechanistic target of rapamycin complex 1

A nutrient- and growth-responsive protein complex that coordinates cell growth with protein synthesis, nutrient use, and autophagy. It contains MTOR, RPTOR, and other subunits; it is not a single protein.

Overview

EXPLORE BY LEVEL

mTORC1 is a team of proteins that works together as one signaling unit. A nutrient- and growth-responsive protein complex that coordinates cell growth with protein synthesis, nutrient use, and autophagy. It contains MTOR, RPTOR, and other subunits; it is not a single protein.

Quick Facts

AT A GLANCE
Molecular formMulti-protein complex
Key subunitsmTOR (MTOR), Raptor (RPTOR), mLST8 (MLST8)

Follow the Connections

See how mTORC1 links to other biological records.

Open network
ProteinmTOR (MTOR)subunit ofProteinRaptor (RPTOR)subunit ofProteinmLST8 (MLST8)subunit ofProteinRHEBactivates
All 6 Structured Connections
mTOR (MTOR) · ProteinSUBUNIT OF →mTORC1 · Molecular complex
Raptor (RPTOR) · ProteinSUBUNIT OF →mTORC1 · Molecular complex
mLST8 (MLST8) · ProteinSUBUNIT OF →mTORC1 · Molecular complex
RHEB · ProteinACTIVATES →mTORC1 · Molecular complex
mTORC1 · Molecular complexACTIVATES →S6K1 (RPS6KB1) · Protein
mTORC1 · Molecular complexPHOSPHORYLATES →4E-BP1 (EIF4EBP1) · Protein

Recommended Reading

Trusted references for learning more about mTORC1.

pathwayMTOR signalling (R-HSA-165159)Reactome · Homo sapiens pathwayPIP3 activates AKT signaling (R-HSA-1257604)Reactome · Homo sapiens pathwaymTORC1-mediated signalling (R-HSA-166208)Reactome · Homo sapiens reviewTargeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapyMolecular Biomedicine · 2022
Research Claims

A nutrient- and growth-responsive protein complex that coordinates cell growth with protein synthesis, nutrient use, and autophagy. It contains MTOR, RPTOR, and other subunits; it is not a single protein.