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Molecular complex

mTORC2

Mechanistic target of rapamycin complex 2

A distinct MTOR-containing complex with RICTOR and other subunits. Among its roles, mTORC2 can phosphorylate AKT at serine 473; it differs in composition and regulation from mTORC1.

Overview

EXPLORE BY LEVEL

mTORC2 is a team of proteins that works together as one signaling unit. A distinct MTOR-containing complex with RICTOR and other subunits. Among its roles, mTORC2 can phosphorylate AKT at serine 473; it differs in composition and regulation from mTORC1.

Quick Facts

AT A GLANCE
Molecular formMulti-protein complex
Key subunitsmTOR (MTOR), RICTOR, mLST8 (MLST8)

Follow the Connections

See how mTORC2 links to other biological records.

Open network
ProteinmTOR (MTOR)subunit ofProteinRICTORsubunit ofProteinmLST8 (MLST8)subunit ofProteinAKT1phosphorylates
All 4 Structured Connections
mTOR (MTOR) · ProteinSUBUNIT OF →mTORC2 · Molecular complex
RICTOR · ProteinSUBUNIT OF →mTORC2 · Molecular complex
mLST8 (MLST8) · ProteinSUBUNIT OF →mTORC2 · Molecular complex
mTORC2 · Molecular complexPHOSPHORYLATES →AKT1 · Protein

Recommended Reading

Trusted references for learning more about mTORC2.

pathwayMTOR signalling (R-HSA-165159)Reactome · Homo sapiens pathwayPIP3 activates AKT signaling (R-HSA-1257604)Reactome · Homo sapiens
Research Claims

A distinct MTOR-containing complex with RICTOR and other subunits. Among its roles, mTORC2 can phosphorylate AKT at serine 473; it differs in composition and regulation from mTORC1.