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Protein

AKT1

AKT serine/threonine kinase 1

A serine/threonine kinase recruited to the membrane by PIP3. AKT1 is phosphorylated by more than one kinase and regulates many targets involved in growth, survival, and metabolism.

Overview

EXPLORE BY LEVEL

AKT1 is a protein that helps pass or control signals inside cells. A serine/threonine kinase recruited to the membrane by PIP3. AKT1 is phosphorylated by more than one kinase and regulates many targets involved in growth, survival, and metabolism.

Quick Facts

AT A GLANCE
Encoded byAKT1
Rolepi3k akt mtor

Follow the Connections

See how AKT1 links to other biological records.

Open network
GeneAKT1encodesPathwayPI3K-AKT-mTOR Signalingparticipates inMoleculePIP3recruitsProteinPDK1 (PDPK1)phosphorylates
All 6 Structured Connections
AKT1 · GeneENCODES →AKT1 · Protein
AKT1 · ProteinPARTICIPATES IN →PI3K-AKT-mTOR Signaling · Pathway
PIP3 · MoleculeRECRUITS →AKT1 · Protein
PDK1 (PDPK1) · ProteinPHOSPHORYLATES →AKT1 · Protein
mTORC2 · Molecular complexPHOSPHORYLATES →AKT1 · Protein
AKT1 · ProteinINHIBITS →TSC1–TSC2 Complex · Molecular complex

Recommended Reading

Trusted references for learning more about AKT1.

pathwayPIP3 activates AKT signaling (R-HSA-1257604)Reactome · Homo sapiens pathwayMTOR signalling (R-HSA-165159)Reactome · Homo sapiens databaseAKT1 (207)NCBI Gene
Research Claims

A serine/threonine kinase recruited to the membrane by PIP3. AKT1 is phosphorylated by more than one kinase and regulates many targets involved in growth, survival, and metabolism.