BASEBiological Archive
for Science & Education
Search
HomeExploreProtein Kinase A (PKA)
Molecular complex

Protein Kinase A (PKA)

cAMP-dependent protein kinase holoenzyme

A cAMP-regulated protein kinase assembled from regulatory and catalytic subunits. cAMP binding to the regulatory subunits can release active catalytic subunits; subunit composition and signaling are context-dependent.

Overview

EXPLORE BY LEVEL

Protein Kinase A (PKA) is a team of proteins that works together as one signaling unit. A cAMP-regulated protein kinase assembled from regulatory and catalytic subunits. cAMP binding to the regulatory subunits can release active catalytic subunits; subunit composition and signaling are context-dependent.

Quick Facts

AT A GLANCE
Molecular formMulti-protein complex
Key subunitsPRKACA catalytic subunit, PKA regulatory subunits (PRKAR1/2 family)

Follow the Connections

See how Protein Kinase A (PKA) links to other biological records.

Open network
MoleculeCyclic AMPactivatesProteinPKA Catalytic subunit alpha (PRKACA)subunit of
All 2 Structured Connections
Cyclic AMP · MoleculeACTIVATES →Protein Kinase A (PKA) · Molecular complex
PKA Catalytic subunit alpha (PRKACA) · ProteinSUBUNIT OF →Protein Kinase A (PKA) · Molecular complex

Recommended Reading

Trusted references for learning more about Protein Kinase A (PKA).

pathwayPKA activation (R-HSA-163615)Reactome · Homo sapiens pathwayG alpha (s) signalling events (R-HSA-418555)Reactome · Homo sapiens
Research Claims

A cAMP-regulated protein kinase assembled from regulatory and catalytic subunits. cAMP binding to the regulatory subunits can release active catalytic subunits; subunit composition and signaling are context-dependent.