Molecule

Cyclic AMP

Cyclic AMP

A small intracellular second messenger made by adenylyl cyclases downstream of selected receptors.

Overview

EXPLORE BY LEVEL

When some receptors are activated, the cell makes cyclic AMP. This small molecule carries the message farther inside the cell.

Quick Facts

AT A GLANCE

Explore nextCell signaling

Follow the Connections

See how Cyclic AMP links to other biological records.

PathwayGPCR Signalingamplifies ProteinAdenylyl Cyclase 5 (ADCY5)produces Molecular complexProtein Kinase A (PKA)activates ProteinPDE4Dhydrolyzes

All 4 Structured Connections

Cyclic AMP · MoleculeAMPLIFIES →GPCR Signaling · Pathway

Adenylyl Cyclase 5 (ADCY5) · ProteinPRODUCES →Cyclic AMP · Molecule

Cyclic AMP · MoleculeACTIVATES →Protein Kinase A (PKA) · Molecular complex

PDE4D · ProteinHYDROLYZES →Cyclic AMP · Molecule

Recommended Reading

Trusted references for learning more about Cyclic AMP.

pathwaySignaling by GPCR (R-HSA-372790)Reactome · Homo sapiens textbookGeneral Principles of Cell CommunicationMolecular Biology of the Cell · NCBI Bookshelf pathwayG alpha (s) activates adenylyl cyclase (R-HSA-163617)Reactome · Homo sapiens pathwayPKA activation (R-HSA-163615)Reactome · Homo sapiens

Show 1 more sources

cAMP degradation by phosphodiesterases (R-HSA-418553)Reactome · Homo sapiens · pathway

Research Claims

cAMP signaling is spatially and temporally organized by cyclases, phosphodiesterases, anchoring proteins, and local receptor inputs. Bulk cAMP measurements may miss compartment-specific signals.

[1] Reactome · Homo sapiens · [2] Molecular Biology of the Cell · NCBI Bookshelf