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HomeMetabolismAcetoacetyl-CoA
MoleculeMETABOLITE RECORD

Acetoacetyl-CoA

A four-carbon thioester formed from two acetyl-CoA molecules on the route to mevalonate.

4-carbon moleculeCholesterol biosynthesisHomo sapiens
REFERENCE IDENTIFIER record
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Learn about Acetoacetyl-CoA

Acetoacetyl-CoA is a small molecule that cells make, use, or change in connected metabolic reactions.

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Record type: molecule. A four-carbon thioester formed from two acetyl-CoA molecules on the route to mevalonate.
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At a glance

Carbon backbone 4 CThis carbon count is shown where it is defined for the molecule.

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Connected records

3 links
Used and produced inCholesterol biosynthesisHandled byAcetyl-CoA acyltransferase 2Handled byHMG-CoA synthase (cytosolic)
STRUCTURED REACTIONS

Where it appears

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1

Acetoacetyl-CoA formation

Thiolase condenses two acetyl-CoA molecules to form acetoacetyl-CoA.

Cholesterol biosynthesis · irreversible
2

HMG-CoA formation

Cytosolic HMG-CoA synthase adds a third acetyl unit to acetoacetyl-CoA.

Cholesterol biosynthesis · irreversible