Carboxylation of pyruvate
Pyruvate gains a carbon dioxide equivalent to form oxaloacetate, using ATP and biotin.
Gluconeogenesis · irreversibleBUILD UP YOUR UNDERSTANDING
Learn about Bicarbonate
Bicarbonate is a small molecule that cells make, use, or change in connected metabolic reactions.
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QUICK FACTS
At a glance
Carbon backbone 1 CThis carbon count is shown where it is defined for the molecule.
FOLLOW THE BIOLOGY
10 linksConnected records
Used inGluconeogenesisUsed inFatty acid synthesisUsed inUrea cycleUsed inPurine nucleotide synthesisUsed inPyrimidine nucleotide synthesisHandled byPyruvate carboxylaseHandled byAcetyl-CoA carboxylaseHandled byCarbamoyl-phosphate synthetase I
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STRUCTURED REACTIONS
Open metabolism map Where it appears
Malonyl-CoA formation
Acetyl-CoA carboxylase uses ATP and biotin to make malonyl-CoA.
Fatty acid synthesis · irreversibleCarbamoyl phosphate synthesis
CPS1 uses two ATP to combine ammonia and bicarbonate into carbamoyl phosphate.
Urea cycle · irreversibleAIR carboxylation
AIR carboxylase adds carbon dioxide to form CAIR.
Purine nucleotide synthesis · irreversibleCarbamoyl phosphate formation
The CAD enzyme complex forms cytosolic carbamoyl phosphate from glutamine and bicarbonate.
Pyrimidine nucleotide synthesis · irreversible