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Protein · enzymePROTEIN · ENZYME RECORD

CAD multifunctional enzyme

Carries out the first three reactions of de novo pyrimidine synthesis: carbamoyl phosphate formation, aspartate addition, and ring closure.

Pyrimidine nucleotide synthesisHomo sapiens
REFERENCE IDENTIFIER6.3.5.5EC record
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CAD multifunctional is a protein that speeds up a chemical reaction. Cells can adjust when and how strongly many enzymes work.

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Record type: enzyme. Carries out the first three reactions of de novo pyrimidine synthesis: carbamoyl phosphate formation, aspartate addition, and ring closure.
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At a glance

HUMAN GENESCADExplore gene
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Connected records

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Catalyzes a step inPyrimidine nucleotide synthesisUsesGlutamineUsesBicarbonateUsesATPProducesCarbamoyl phosphateProducesGlutamateProducesADPProducesInorganic phosphate
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UsesCarbamoyl phosphateUsesAspartateProducesDihydroorotateUsesUridine monophosphateProducesUridine triphosphateProducesCytidine triphosphateEncoded byCAD
STRUCTURED REACTIONS

Reactions it catalyzes

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1

Carbamoyl phosphate formation

The CAD enzyme complex forms cytosolic carbamoyl phosphate from glutamine and bicarbonate.

Pyrimidine nucleotide synthesis · irreversible
6

UTP and CTP formation

Downstream phosphorylation and CTP synthetase convert UMP through UDP and UTP, then make CTP.

Pyrimidine nucleotide synthesis · irreversible