Transamination
BCAT transfers amino groups to alpha-ketoglutarate, forming glutamate and the corresponding keto acids.
Branched-chain amino acid catabolism · reversibleBUILD UP YOUR UNDERSTANDING
Learn about Glutamate
Glutamate is a small molecule that cells make, use, or change in connected metabolic reactions.
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QUICK FACTS
At a glance
Carbon backbone 5 CThis carbon count is shown where it is defined for the molecule.
FOLLOW THE BIOLOGY
8 linksConnected records
Produced inBranched-chain amino acid catabolismProduced inPurine nucleotide synthesisProduced inPyrimidine nucleotide synthesisHandled byBranched-chain amino-acid aminotransferaseHandled byGlutamine phosphoribosylpyrophosphate amidotransferaseHandled byFGAM synthetaseHandled byGMP branch enzymesHandled byCAD multifunctional enzyme
STRUCTURED REACTIONS
Open metabolism map Where it appears
Committed purine nitrogen addition
Glutamine-PRPP amidotransferase commits PRPP to de novo purine synthesis.
Purine nucleotide synthesis · irreversibleGlutamine-dependent nitrogen addition
FGAM synthetase supplies another ring nitrogen from glutamine.
Purine nucleotide synthesis · irreversibleGMP branch
The GMP branch oxidizes IMP to XMP and adds nitrogen from glutamine using ATP.
Purine nucleotide synthesis · irreversibleCarbamoyl phosphate formation
The CAD enzyme complex forms cytosolic carbamoyl phosphate from glutamine and bicarbonate.
Pyrimidine nucleotide synthesis · irreversibleUTP and CTP formation
Downstream phosphorylation and CTP synthetase convert UMP through UDP and UTP, then make CTP.
Pyrimidine nucleotide synthesis · irreversible