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MoleculeMETABOLITE RECORD

Glutamine

An amino acid that donates nitrogen in nucleotide synthesis and other biosynthetic reactions.

5-carbon moleculePurine nucleotide synthesisHomo sapiens
REFERENCE IDENTIFIERCHEBI:18050ChEBI record
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Learn about Glutamine

Glutamine is a small molecule that cells make, use, or change in connected metabolic reactions.

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Record type: molecule. An amino acid that donates nitrogen in nucleotide synthesis and other biosynthetic reactions.
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At a glance

Carbon backbone 5 CThis carbon count is shown where it is defined for the molecule.

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Connected records

6 links
Used inPurine nucleotide synthesisUsed inPyrimidine nucleotide synthesisHandled byGlutamine phosphoribosylpyrophosphate amidotransferaseHandled byFGAM synthetaseHandled byGMP branch enzymesHandled byCAD multifunctional enzyme
STRUCTURED REACTIONS

Where it appears

Open metabolism map
2

Committed purine nitrogen addition

Glutamine-PRPP amidotransferase commits PRPP to de novo purine synthesis.

Purine nucleotide synthesis · irreversible
5

Glutamine-dependent nitrogen addition

FGAM synthetase supplies another ring nitrogen from glutamine.

Purine nucleotide synthesis · irreversible
1

Carbamoyl phosphate formation

The CAD enzyme complex forms cytosolic carbamoyl phosphate from glutamine and bicarbonate.

Pyrimidine nucleotide synthesis · irreversible
6

UTP and CTP formation

Downstream phosphorylation and CTP synthetase convert UMP through UDP and UTP, then make CTP.

Pyrimidine nucleotide synthesis · irreversible