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MoleculeMETABOLITE RECORD

NADPH

Reduced nicotinamide adenine dinucleotide phosphate; it supplies reducing power for biosynthesis and antioxidant defense.

Pentose phosphate pathwayHomo sapiens
REFERENCE IDENTIFIERCHEBI:16474ChEBI record
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Record type: molecule. Reduced nicotinamide adenine dinucleotide phosphate; it supplies reducing power for biosynthesis and antioxidant defense.
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Connected records

8 links
Produced inPentose phosphate pathwayUsed inFatty acid synthesisUsed inCholesterol biosynthesisHandled byGlucose-6-phosphate dehydrogenaseHandled by6-Phosphogluconate dehydrogenaseHandled byFatty acid synthaseHandled byHMG-CoA reductaseHandled bySqualene synthase
STRUCTURED REACTIONS

Where it appears

Open metabolism map
1

Oxidation of glucose 6-phosphate

G6PD oxidizes glucose 6-phosphate and reduces NADP+ to NADPH.

Pentose phosphate pathway · irreversible
3

Oxidative decarboxylation

6-Phosphogluconate dehydrogenase releases CO2 and makes a second NADPH.

Pentose phosphate pathway · irreversible
5

Reduction, dehydration, and second reduction

FASN reduces the keto group, removes water, and reduces the double bond to yield a saturated chain two carbons longer.

Fatty acid synthesis · irreversible
10

Squalene formation

Squalene synthase reductively joins two farnesyl diphosphate molecules.

Cholesterol biosynthesis · irreversible