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Protein · enzymePROTEIN · ENZYME RECORD

Fatty acid synthase

Multifunctional enzyme that repeatedly extends an acyl chain to palmitate using malonyl units and NADPH.

Fatty acid synthesisHomo sapiens
REFERENCE IDENTIFIER2.3.1.85EC record
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Learn about Fatty acid synthase

Fatty acid synthase is a protein that speeds up a chemical reaction. Cells can adjust when and how strongly many enzymes work.

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Record type: enzyme. Multifunctional enzyme that repeatedly extends an acyl chain to palmitate using malonyl units and NADPH.
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At a glance

HUMAN GENESFASNExplore gene
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Connected records

13 links
Catalyzes a step inFatty acid synthesisUsesAcetyl-CoAProducesGrowing fatty acyl-ACPUsesGrowing fatty acyl-ACPUsesMalonyl-CoAUsesCoenzyme AProduces3-Ketoacyl-ACPProducesCarbon dioxide
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Uses3-Ketoacyl-ACPUsesNADPHProducesNADP+ProducesPalmitateEncoded byFASN
STRUCTURED REACTIONS

Reactions it catalyzes

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3

Acetyl primer loading

The acetyl primer is loaded onto the acyl carrier protein of fatty acid synthase.

Fatty acid synthesis · irreversible
4

Malonyl condensation

Decarboxylative condensation adds two carbons from malonyl-CoA.

Fatty acid synthesis · irreversible
5

Reduction, dehydration, and second reduction

FASN reduces the keto group, removes water, and reduces the double bond to yield a saturated chain two carbons longer.

Fatty acid synthesis · irreversible
6

Palmitate release

FASN thioesterase releases palmitate, its principal product.

Fatty acid synthesis · irreversible