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MoleculeMETABOLITE RECORD

Oxaloacetate

A four-carbon citric acid cycle intermediate and gluconeogenic precursor.

4-carbon moleculeGluconeogenesisHomo sapiens
REFERENCE IDENTIFIERCHEBI:16452ChEBI record
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Learn about Oxaloacetate

Oxaloacetate is a small molecule that cells make, use, or change in connected metabolic reactions.

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Record type: molecule. A four-carbon citric acid cycle intermediate and gluconeogenic precursor.
QUICK FACTS

At a glance

Carbon backbone 4 CThis carbon count is shown where it is defined for the molecule.

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Connected records

8 links
Used and produced inGluconeogenesisUsed and produced inCitric acid cycleProduced inFatty acid synthesisHandled byPyruvate carboxylaseHandled byPhosphoenolpyruvate carboxykinase (cytosolic)Handled byCitrate synthaseHandled byMitochondrial malate dehydrogenaseHandled byATP-citrate lyase
STRUCTURED REACTIONS

Where it appears

Open metabolism map
1

Carboxylation of pyruvate

Pyruvate gains a carbon dioxide equivalent to form oxaloacetate, using ATP and biotin.

Gluconeogenesis · irreversible
2

Conversion of oxaloacetate to phosphoenolpyruvate

PEP carboxykinase uses GTP to decarboxylate and phosphorylate oxaloacetate.

Gluconeogenesis · irreversible
1

Citrate formation

Citrate synthase condenses acetyl-CoA and oxaloacetate.

Citric acid cycle · irreversible
8

Oxaloacetate regeneration

Malate dehydrogenase oxidizes malate to oxaloacetate and NADH.

Citric acid cycle · irreversible
1

Cytosolic acetyl-CoA supply

ATP-citrate lyase provides cytosolic acetyl-CoA from exported citrate.

Fatty acid synthesis · irreversible