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HomeMetabolismATP-citrate lyase
Protein · enzymePROTEIN · ENZYME RECORD

ATP-citrate lyase

Uses ATP and coenzyme A to cleave cytosolic citrate into acetyl-CoA and oxaloacetate.

Fatty acid synthesisHomo sapiens
REFERENCE IDENTIFIER2.3.3.8EC record
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Record type: enzyme. Uses ATP and coenzyme A to cleave cytosolic citrate into acetyl-CoA and oxaloacetate.
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Catalyzes a step inFatty acid synthesisUsesCitrateUsesCoenzyme AUsesATPProducesAcetyl-CoAProducesOxaloacetateProducesADPProducesInorganic phosphate
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Encoded byACLY
STRUCTURED REACTIONS

Reactions it catalyzes

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Cytosolic acetyl-CoA supply

ATP-citrate lyase provides cytosolic acetyl-CoA from exported citrate.

Fatty acid synthesis · irreversible