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Pathway

p53 Signaling

p53-dependent stress response

A connected response in which stress signals stabilize p53 and influence cell-cycle arrest, repair, or apoptosis.

REACTOME IDENTIFIERR-HSA-69541View source record ↗

Overview

EXPLORE BY LEVEL

Cells use this network to respond to damage. Signals can raise p53 levels, and p53 can then help slow cell division or direct other protective responses.

Quick Facts

AT A GLANCE
SpeciesHomo sapiens
Featured eventStabilization of p53
Associated outputCell-cycle response

Follow the Connections

See how p53 Signaling links to other biological records.

Open network
Proteinp53participates inGeneCDKN1Aincludes
All 2 Structured Connections
p53 · ProteinPARTICIPATES IN →p53 Signaling · Pathway
p53 Signaling · PathwayINCLUDES →CDKN1A · Gene

Recommended Reading

Trusted references for learning more about p53 Signaling.

pathwayStabilization of p53 (R-HSA-69541)Reactome reviewUnravelling mechanisms of p53-mediated tumour suppressionNature Reviews Cancer · PMID 24739573
Research Claims

Reactome describes stabilization of p53 within the human DNA-damage checkpoint hierarchy.